1983年9月出生，英国布里斯托大学医学院博士、博士后。中山大学本科、硕士。2012年5月回国加盟内蒙古大学生命科学院。研究兴趣为DNA复制与肿瘤发生，主要研究DNA复制与地方性高发肿瘤的内在联系、研究传统蒙药的抗癌机理、研究Rho小G蛋白与肿瘤的迁移与浸润。主要研究成果发现了化学合成的降脂药物胡椒酸钾对乳腺肿瘤细胞的增殖有较强的抑制作用，并且可以特异性阻止乳腺肿瘤细胞的G1/S转接，抑制乳腺肿瘤细胞DNA复制并诱导乳腺肿瘤细胞凋亡。发现了非典型Rho小G蛋白Rif具有多重功能：1）Rif作为细胞骨架调节因子可以诱导产生重要的stress fiber和filopodia细胞骨架结构;2)Rif小G蛋白不仅可以发挥G蛋白激酶活性，激发下游信号通路，还可以作为调节分子来调节其他小Rho蛋白的活性,抑制神经突的生成。

现任生物化学与分子生物学学科副教授、硕士生导师。

电子邮件：lifei.fan@imu.edu.cn      

通信地址：内蒙古呼和浩特市大学西路235号

内蒙古大学生命科学学院主楼153A，邮编010021

研究方向：

（1）癌细胞DNA复制生物学

（2）Rho小G蛋白家族与肿瘤的迁移与浸润，Rho小G蛋白家族成员功能探索

Representative Publications:

DNA replication and cancer

(1) Fan L*, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen M*.The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis. Oncotarget. 2017 Apr 12. doi: 10.18632/oncotarget.16872. (*Corresponding authors)

(2) Yao Y ^#, Fan L ^#, Shi Y, Odsbu I, Morigen*. A Spatial Control for Correct Timing of Gene Expression during the Escherichia coli Cell Cycle.Genes (Basel). 2016 Dec 23; 8(1). pii: E1. doi: 10.3390/genes8010001.（^# Co-first authors）

(3)Wurihan, Wunier, Li H, Fan L*, Morigen*. Trans-translation ensures timely initiation of DNA replication and DnaA synthesis in Escherichia coli.Genet Mol Res. 2016 Aug 29;15(3). doi: 10.4238/gmr.15038407. (*Corresponding authors)

(4) Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L*, Morigen*, AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle. PLoS One. 2014 Mar 26;9(3):e92229. doi: 10.1371/journal.pone.0092229. eCollection 2014. (*Corresponding authors)

The functions of small Rho GTPases

(1) Tian X, Yan H, Li J, Wu S, Wang J, Fan L*. Neurotrophin promotes neurite outgrowth by inhibiting Rif GTPase activation downstream of MAPKs and PI3K signaling.Int J Mol Sci. 2017 Jan 13;18(1). pii: E148. doi: 10.3390/ijms18010148. (*Corresponding author)

(2) Fan L, Yan H, Pellegrin S, Morigen, Mellor H.The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction. Neurosci Lett. 2015 Mar 17;590:178-83. doi: 10.1016/j.neulet.2015.02.010. Epub 2015 Feb 7.（First author）

(3) Fan L, Morigen. Rho and Ras GTPases in semaphorin-mediated neuronal development. Advances in Bioscience and Biotechnology. PP. 136-142, Pub. Date: January 31, 2013.（First author）

(4) Fan L,Mellor H. The small Rho GTPase Rif and actin cytoskeletal remodelling.Biochem Soc Trans. 2012 Feb;40(1):268-72.（First author）

(5) Fan L, Pellegrin S, Scott A, Mellor H. The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells. J Cell Sci. 2010 Apr 15;123 (Pt 8):1247-52.（First author）

其他论文: Other Publications:

(1) Han F, Fan L, Wang X, Li W. Sulforhodamine B restaining as a whole-cell label allows visualizing one more fluorochrome and its application in assaying protein nucleocytoplasmic distribution.Cytometry A. 2012 Jun;81(6):532-40.

(2) Han Y, Huang G, Zhang Q, Yuan S, Liu J, Zheng T, Fan L, Chen S, Xu A. The primitive immune system of amphioxus provides insights into the ancestral structure of the vertebrate immune system. Dev Comp Immunol. 2010 Aug;34(8):791-6.

(3) Huang G, Liu H, Han Y, Fan L, Zhang Q, Liu J, Yu X, Zhang L, Chen S, Dong M, Wang L, Xu A. Profile of acute immune response in Chinese amphioxus upon Staphylococcus aureus and Vibrio parahaemolyticus infection. Dev Comp Immunol. 2007;31(10):1013-23.

(4) Huang G, Xie X, Han Y, Fan L, Chen J, Mou C, Guo L, Liu H, Zhang Q, Chen S, Dong M, Liu J, Xu A. The identification of lymphocyte-like cells and lymphoid-related genes in amphioxus indicates the twilight for the emergence of adaptive immune system. PLoS One. 2007 Feb 14;2(2):e206