内蒙古大学 生命科学学院 & 实验动物研究中心

Research Center for Laboratory Animal Science

& College of Life Science,

Inner Mongolia University

24 Zhao Jun Road, Hohhot,

Inner Mongolia Autonomous Region , 010070,

P. R. China

Tel: ++8 6-471-529-4030 ；

E-mail: bhexig@mongol-ncf.com;  bayar98@hotmail.com

贺喜白乙 教授：男，蒙古族， 1972年出生于内蒙古库伦旗，博士， 2012年内蒙古大学引进的高层次人才。

2005年 3月在日本东京工业大学获得博士学位。 2005-2007年在日本国立医药品食品卫生研究所作博士后。

2007-2012年在东京工业大学生命理工学研究科任助理教授。长期从事干细胞在再生医学上的应用研究。研究工作涉及干细胞学，发育生物学，生物功能材料与再生医学，生物 -纳米界面等交叉领域。曾分担两项日本科学振兴会的重大项目和一项日本文部省再生医学实现化的重大委托事业项目。发表研究论著 1部，研究论文 20多篇，其中 SCI论文 14篇，还有授权国际专利 2项。

学术贡献：

1、研发了可反复“单一细胞级”干细胞培养系统，彻底改变了多能干细胞培养过程中存在的由于细胞团块而无法形成单层且保持多能性的缺陷；

2、研发了无损伤均匀增殖胚胎干细胞和诱导干细胞的大量培养系统，在控制干细胞的功能方面取得了卓越的成就，研究成果领先于国际同行的研究水平；

3、开发了高效率定向分化诱导干细胞到成熟肝脏细胞的技术和高效率筛选目的功能细胞的技术；

4、提出了新的临床医疗 -生物材料细胞毒性评价方法 。

近年发表的代表性论文（著）：

1.         S. Sakai, J. Kim, B. Hexig, Y. Okahata, C.S. Cho, T. Akaike. Adsorption behaviors of recombinant E-cadherin-IgG Fc fusion protein on polystyrene surface. Colloids and Surfaces B: Biointerfaces 1; 94: 192- 198, 2012 .

2.         Qingyuan Meng, Amranul Haque, Bayar Hexig, Toshihiro Akaike. The differe ntiation and isolation of mouse embryonic stem cells toward hepatocytes using galactose-carrying substrata . Biomaterials. 33, 1414-1427 , 2012.

科研项目和成果：

（1）   研发细胞活性型融合蛋白质细胞外基质而控制 ES/iPS细胞的功能和分化过程。基盘研究 S（日本科学振兴会） 2011-2014 ，分担研究者

（2）   以钙粘素融合蛋白质作为细胞外基质的 ES/iPS细胞的单一细胞级培养系统的开发。（日本文部省委托研究事业） “第二期再生医疗实现项目” 2008-2010， 分担负责项目执行

（3）   研发单一细胞级培养系统和刺激反应探测系统而分析 ES细胞的彷徨变异的机制。基盘研究 C，日本科学振兴会  2009-2011   分担研究者

（4）   研究分析高分子表面和可固定性融合蛋白之间的相互作用、共固定融合蛋白质的机制   东京工业大学 GCOE 青年学者奖励金 2008-2009  主持

Research interests                                                        

Stem cell biology; Developmental biology; Directed d ifferentiation; Cell reprograming; Regenerative medicine; Biomaterials; Na no -biointerface

Research Experience                                                        
 2012-Present   Professor, Research Center for Laboratory Animal Science & College of Life Science,              Inner Mongolia University, P. R. China

200 8 - 2012              A ssistant professor , Graduate School of Bioscience and Biotechnology & Frontier Research Center,   Tokyo Institute of Technology , Japan

？ Evolving Education and Research Center for Spatio-Temporal Biological Network

200 7 - 2008       Researcher, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology , Japan

？ Evolving Education and Research Center for Spatio-Temporal Biological Network

2005 - 2007       Postdoctoral Researcher, Division of Medical Devices, National Institute of Health Science , Japan

？ Health and Labor Sciences Grants for Research on Advanced Medical Technology and Risk Analysis on Food and Pharmaceuticals by Ministry of Health, Labor and Welfare

Education　　　　　　　　　　　　　　　　        　 　　　             　    　  　　

2005                         Ph . D . in Biomolecular Engineering, Tokyo Institute of Technology , Japan

2001                        M.Sc. in Biological & Chemical Engineering, Gunma University, Japan

1994                         B . S c. in Physic s , Inner Mongolia Normal University , China

Grants & Funding                                                          

2013-2015      Project leader

              Supported by Program of Higher-level talents of Inner Mongolia University (SPH-IMU)  

             

2011- 2014           Project member

Project: Regulation of functions and differentiation of ES/iPS cells by designing cell-recognizable chimera matrices

2008-2011       Project member

The Project for Realization of Regenerative Medicine; sponsored by Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan

Project: Development of novel single cell level culture system for ES/iPS cells based on E-cadherin chimeric protein matrix

200 9 -2011         Project member

Grants-in Aid for Specific Research (C) (JSPS), Japan

                Project: Single-cell microscopy with stimulus and response device to analyze relaxation mechanism

                       of ES cells fluctuation

Selected peer-reviewed publications                                        

1.     S. Sakai, J. Kim, B. Hexig , Y. Okahata, C.S. Cho, T. Akaike. Adsorption behaviors of recombinant E-cadherin-IgG Fc fusion protein on polystyrene surface. Colloids and Surfaces B: Biointerfaces , 94:192-198, 2012.

2.     Qingyuan Meng, Amranul Haque, Bayar Hexig , Toshihiro Akaike. The differentiation and isolation of mouse embryonic stem cells toward hepatocytes using galactose-carrying substrata. Biomaterials , 33:1414-1427, 2012.

Book chapter and review papers                                            
1.   Alata Hexigand Bayar Hexig.Characterization of c ompositional g radient s tructure of p olymeric m aterials by FT-IR t echnology, Theophanides Theophile, Infrared Spectroscopy/ Book 1, Croatia, INTECH open access publisher, 2012 .

2.   Bayar Hexig , Toshihiro Akaike. Development of large scale culture system for ES and iPS cells based on E-cadherin coated substrate.Journal of Clinical and Experimental Medicine (IGAKU NO AYUMI) , 238, 1181- 1187, 201 1         (in Japanese) . 　　

3.   Bayar Hexig , Toshihiro Akaike. Non-stress homogeneous ES/iPS cells culture system for large scale production , Regenerative Medicine , 9, 323-331, 2010 (in Japanese).

4.   Bayar Hexig , Meng QingYuan, Toshihiro Akaike. T he t echnology of n ano-fiber i nnovate r egenerative m edicine , Engineering Materials , 58, 42-47, 2010 (in Japanese).

5.   Md Amranul Haque, Masato Nagaoka, Bayar Hexig and Toshihiro Akaike. Artificial extracellular matrix for embryonic stem cell cultures: a new frontier of nanobiomaterials. Sci. Technol. Adv. Mater . 11, 1-9, 2010.

Selected conference presentations                                        

1.       Bayar Hexig, Toshihiro Akaike. Large s cale n on-stress h omogeneous p roliferation of ES/iPS c ells on E-cadherin c himeric n ano-material . The 3^rd Asian Biomaterials Congress, Busan, KOREA .                         ( September , 2011 )

2.       Bayar Hexig, Toshihiro Akaike Stress-free culture system for ES/iPS cells . The 9^th Congress of the Japanese Society for Regenerative Medicine. Hiroshima, Japan .                                                   (March , 2010)

3.       Bayar Hexig, Toshihiro Akaike. Application of cell recognizable matrix-coated nano-fib er network scaffolds for regenerative medicine . The 7^th Congress of the Japanese Society for Regenerative Medicine. Nagoya, Japan (March 2008)  

4.       Bayar Hexig. Development of E-cadherin/Fc-based 3D culture system for large-scale ES/iPS cells production. The 2nd Annual Congress of Regenerative Medicine & Stem Cell, Dalian, China.         (August, 2009) （ Invited Presentatio n )

5.       Bayar Hexig, Toshihiro Akaike. Development of E-cadherin/Fc-based 3D culture system for large-scale ES/iPS cells production. 2^nd TERMIS World Congress & 2009 Seoul Stem Cell Symposium, Seoul, Korea.       (September, 2009)

6.       Bayar Hexig, Toshihiro Akaike. Development of 3D culture system for large-scale ES/iPS cells production . 2008 Annual Conference of Tissue Engineering and Regenerative Medicine International Society - Asian Pacific Region, (TERMIS-AP-2008) Taipei, Taiwan .                                                      ( November , 2008 )

Professional service                                                      

Organization member of international symposium of GCOE program ( Evolving Education and Research Center for Spatio-Temporal Biological Network), Tokyo Institute of Technology

  The 7^th GCOE international symposium on Nano-biomaterials Science and Technology for Medicine and Biology