莫日根（Morigen），2005年毕业于挪威奥斯陆大学医学院分子生物学专业，获博士学位。之后在挪威肿瘤医院癌症研究所做博士后研究。2009年10月回国任内蒙古大学生命科学学院生物化学与分子生物学教授、博士生导师。

现任生命科学学院院长、内蒙古自治区细胞分子调控重点实验室主任、内蒙古自治区细胞分子工程技术研究中心主任、省部共建草原家畜生殖调控与繁育国家重点实验室副主任。兼任内蒙古遗传学会副理事长、中国遗传学会微生物专业委员会委员、中国细胞生物学会理事、《高校生物学教学研究（电子版）》编委、《中国细胞生物学学报》编委、《中国生物化学与分子生物学报》编委。

Email：morigenm@life.imu.edu.cn

 

一、研究领域和兴趣：

 

1. 细菌DNA复制、细胞周期及环境适应分子机制与耐药性。主要以大肠杆菌为模式生物，研究DNA复制与基因组稳定、细胞周期、代谢和基因表达调控分子机制，揭示细胞环境适应性和耐药性分子机理。

2. 癌细胞DNA复制与基因组稳定性。

 

Research interests:

 

1. The Escherichia coli DNA replication, cell cycle and environmental adaptation.

2. DNA replication in cancer cells.

 

二、相关学术论文：

1. Wurihan, Gezi, Brambilla E, Wang S, Sun H, Fan L, Shi Y1, Sclavi B*, Morigen*

DnaA and LexA proteins regulate transcription of the uvrB gene in Escherichia coli: the role of DnaA in the control of the SOS regulon, Front Microbiol, 9:1212, https://doi.org/10.3389/fmicb.2018.01212, 2018.

2. Yao Y, Enkhtsetseg S, Odsbu I, Fan L, Morigen*

Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1–1 plasmid, BMC Microbiol, 18:27, https://doi.org/10.1186/s12866-018-1162-3, 2018.

3.Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen*

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis, Oncotarget, doi:10.18632/oncotarget.16872, 2017.

4.Yao Y, Fan L, Shi Y, Odsbu I, Morigen*

A spatial control for correct timing of gene expression during the Escherichia coli cell cycle, Genes, 8(1), 1: doi:10.3390/genes8010001, 2017.

5. Wurihan, Wunier, Li H, Fan L, Morigen*

Trans-translation ensures timely initiation of DNA replication and DnaA synthesis in Escherichia coli, Gent Mol Res, 15 (3): gmr.15038407, 2016.

6. Yao Y, Wunier, Morigen*

Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli,Gent Mol Res, 14(4):16888-16895, 2015.

7. Fan L, Yan H, Pellegrin S, Morigen*, Mellor H

The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction, Neurosci Lett, 590(-):178-183, 2015.

8. Dong Q, Dong A, Morigen*

Evaluation of novel antibacterial N-halamine nanoparticles prodrugs towards susceptibility of Escherichia coli induced by DksA protein, Molecules, 21;20(4):7292-308, 2015.

9. Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L, Morigen*

AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle, PLoS ONE, 9(3):e92229, 2014.

10.Morigen, Flatten I, Skarstad K

The Escherichia coli  datA  site promotes proper regulation of cell division, SGM-Microbiol, 160(4):703-710, 2014.

11. Johnsen L, Flatten I, Morigen, Dalhus B, Bjoras M, Waldminghaus T, Skarstad K

TheG157C mutation in the Escherichia coli sliding clamp specifically affects initiation of Replication, Mol Microbiol , 79(2):433-446, 2011.

12.Weatherspoon-Griffin N, Zhao G, Kong W,Kong Y,Morigen,Andrews-Polymenis H,McClelland M, Shi Y

The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide, J Biol Chem, 286(7):5529-39, 2011.

13.Morigen, Odsbu I, Skarstad K

Growthrate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing Escherichia coli,Genes Cells, 14(5):643-657, 2009.

14. Wang J, Morigen

BayesPI--a new model to study protein-DNA interaction: a case study of condition-specific protein binding parameters for yeast transcription factors, BMC Bioinformatics, 10:345, 2009.

15. Odsbu I., Morigen, Skarstad K

A reductionin ribonucleotide reductase activity slows down the chromo some replication fork but does not change its localization, PLoS ONE, 4(10):e7617, 2009.

16. Flatten I, Morigen, Skarstad K

DnaAprotein interacts with RNA polymerase and protects it from the effect of rifampicin, Mol Microbiol,71(4):1018-1030,2009.

17. Bach T, Morigen, Skarstad K

The initiator protein DnaA contributes to keeping new origins inactivated by promoting the presence of hemi methylated DNA, J Mol Biol, 384(5):1076-85, 2008.

18.Morigen, Molina F, Skarstad K

Deletionof the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication, J Bacteriol, 187(12):3913-20, 2005.

19. Morigen, Lobner-Olesen A, Skarstad K

Titration of the Escherichia coli DnaA protein to excess datAsites causes destabilization of replication forks, delayed replication initiation and delayed cell division, Mol Microbiol, 50:349-362, 2003.

20. Morigen, Boye E, Skarstad K, Lobner-Olesen A

Regulation of chromosomal replication by DnaA protein availability in Escherichia coli: effects of the datA region, Biochim Biophys Acta, 1521: 73-80,2001.

21. Weigel C, Messer W, Preiss S, Welzeck M, Morigen, Boye E

Thesequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome, Mol Microbiol, 40(2): 498-507, 2001.