科研项目

1.国家自然科学基金青年项目，主持，在研

2.博士后创新人才支持计划，主持，已结题

3.博士后基金面上资助一等，主持，已结题

4.中国科学院特别研究助理资助项目，主持，已结题

代表性论文（#并列一作，*通讯作者）：

1. Li, M.*,#, Gong, L.#, Cheng, F.#, Yu, H., Zhao, D., Wang, R., Wang, T., Zhang, S., Zhou, J., Shmakov, S., Koonin, E., Xiang, H.*, (2021) Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems. Science, 372(6541): eabe5601.

2. Liu, C.#, Wang, R.#, Li, J#, Cheng, F.#, Shu, X.#, Zhao, H., Xue, Q., Yu, H., Wu, A., Wang, L., Hu, S., Zhang, Y., Yang, J., Xiang, H.*, Li, M.*. (2023) Widespread RNA-based cas regulation monitors crRNA abundance and anti-CRISPR proteins. Cell Host Microbe, 31(9):1481-1493.

3. Cheng, F.#, Wu, A.#, Liu, C.#, Cao, X., Wang, R., Shu, X., Wang, L., Zhang, Y., Xiang, H.*, Li, M.*, (2022) The toxin-antitoxin RNA guards of CRISPR-Cas evolved high specificity through repeat degeneration. Nucleic Acids Research, 50(16): 9442-9452.

4. Cheng, F.#, Wang, R.#, Yu, H.#, Liu, C., Yang, J., Xiang, H.*, Li, M.*, (2021) Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins. Nucleic Acids Research, 49(18):10677-10688.

5. Cheng, F.*,#, Wu, A.#, Li, Z., Xu, J., Cao, X., Yu, H., Liu, Z., Wang, R., Han, W., Xiang, H.*, Li, M.*, (2024) Catalytically active prokaryotic Argonautes employ phospholipase D family proteins to strengthen immunity against different geneti invaders. mLife, 3(3): 403-416.

6. Cheng, F., Gong, L., Zhao, D., Yang, H., Zhou, J., Li, M.*, Xiang, H.*. (2017) Harnessing the native type I-B CRISPR-Cas for genome editing in a polyploid archaeon. Journal of Genetics and Genomics, 44(11):541-548. （封面文章）