科研项目：

国家自然科学基金，青年项目，32300055，双环吉玛烯合成酶晶体结构解析及其远端位点调控的催化机制研究，2024.01至2026.12，30万，主持，在研。

中国博士后科学基金，面上项目，2023M742602，香橙烯型倍半萜合酶Agr5的柔性氨基酸残基催化反应中间体羟化的机制研究，2023.11至2024.12，8万，主持，已结题。

企业横向，秸秆生物发酵法用酶系统开发，2023.07至2024.06，20万元，主持，已结题。

浙江省“尖兵”、“领雁”科技计划，2025C01102，基因调控元件工程化设计关键技术与生物制造应用，2025.01至2026.12，900万，参与。

绍兴“名士之乡”英才计划-领军人才创业项目，2024.08至2027.12，200万，参与。

发表文章：

1. Lin Guo‡, Xiaoguang Yan‡*, Yali Lu‡, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao*, Boxue Tian*. Enhancing Enzyme Activity with Mutation Combinations Guided by Few-shot Learning and Causal Inference. Angewandte Chemie International Edition.2026. （1区Top, IF=17.6）

2. Jiahui Zhou^#, Xiaoguang Yan^#*, Mingyue Ge^#, Jiaqi Lin, Shengxin Nie, Yue Qu, Weiguo Li, Shengbo Wu, Qinggele Caiyin, Warispreet Singh, Jianjun Qiao^*, Meilan Huang^*. Natural Products of Sesquiterpene Synthases by Mechanism-Based Design and DeEnzyme_Score Screening. ACS Catalysis 2026, 16, 13022−13032. （1区Top, IF=13.6）

3.Xiaoguang Yan^#, Jiahui Zhou^#, Jianjun Ge^#, Weiguo Li, Dongmei Liang, Warispreet Singh, Gary Black, Shengxin Nie, Jian Liu, Meiqing Sun, Jianjun Qiao^*, Meilan Huang^*. Computer-informed engineering: A new class I sesquiterpene synthase JeSTS4 for the synthesis of an unusual C10-(S)-bicyclogermacrene. ACS Catalysis. 2022, 12 (7): 4037-4045. （1区Top, IF=13.6）

4. Tingting Niu^#, Xiaoguang Yan^#, Jingru Wang, Hongjian Song, Yi Cui, Xiangping Cai, Alan Kueichieh Chang, Jianjun Qiao^*, Mingzhang Wen^*, Jianwei He^*. Engineering of Pichia pastoris for the de novo synthesis of the sesquiterpene zealexin A1 from methanol. ACS Sustainable Chemistry & Engineering. 2024, 12 (34): 12786-12794. （1区Top, IF=8.4）

5. Yukun Li, Ran Li, Jianjun Ge, Shengxin Nie, Ruiqi Chen, Xiaoguang Yan^*, Jianjun Qiao^*. Comprehensive engineering strategies for heterologous production of zealexin a1 in Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 2024, 72 (34): 19071-19080. （1区Top, IF=6.1）

6. Shengxin Nie#, Shengli Wang#, Ruiqi Chen, Mingyue Ge, Xiaoguang Yan^*, Jianjun Qiao*. Catalytic mechanism and heterologous biosynthesis application of Sesquiterpene Synthases. Journal of Agricultural and Food Chemistry, 2024, 72 (13): 6871-6888. （1区Top, IF=6.1）

7. Xiaoguang Yan, Ran Ye, Ye Chen^*. Blasting extrusion processing: the increase of soluble dietary fiber content and extraction of soluble-fiber polysaccharides from wheat bran. Food Chemistry, 2015, 180: 106-115. （1区Top, IF=9.8）

8. Weiguo Li^#, Xiaoguang Yan^#, Yuting Zhang, Dongmei Liang, Qinggele Caiyin, Jianjun Qiao^*. Characterization of trans-nerolidol synthase from Celastrus angulatus Maxim and production of trans-nerolidol in engineered Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 2021, 69 (7): 2236-2244. （1区Top, IF=6.1）

9. Shengxin Nie, Ruiqi Chen, Mingyue Ge, Yu Qu, Xiaofeng Liu, Chaofeng Ruan, Xiaoguang Yan^*, Jianjun Qiao^*. Biosynthesis of irregular monoterpene lavandulol in Saccharomyces cerevisiae. Synthetic and Systems Biotechnology, 2025,10:1267–1274. （1区Top, IF=4.4）

10. Shengxin Nie#, Pengyuan Wang#, Mingyue Ge, Yue Qu, Yuan Zhu, Jiaqi Lin, Guangzhao Du, Qinggele Caiyin*, Xiaoguang Yan*, Jianjun Qiao*. Patchoulol: Bioactive Properties, Synthase Catalytic Mechanisms, and Biosynthetic Progress ── a Review. ACS Synthetic Biology, 2025, 14 (12), 4636-4653. （2区, IF=4.7）