1.科研项目

主持在研和完成的科研项目：

国家自然科学基金项目7项

内蒙古自然科学基金重大项目等2项

内蒙古科技计划项目2项

内蒙古高等学校创新团队发展计划项目1项

内蒙古党委组织部草原英才及其滚动支持项目各1项

2.科学发现

发现并揭示复制起始蛋白DnaA介导的转录衰减新型核糖开关（见下图）；揭示DnaA对DNA复制与修复、基因表达的调控机制；发现QseBC信号通路调控dnaA基因表达；发现基因表达的空间调控新模式；发现快速复制引发复制叉之间的相互分离和高频自发突变；发现天冬氨酸代谢对细胞周期的协同作用。

3.代表性论文

发表学术论文60余篇，其中SCI期刊论文41篇。

（1）Yao Y, Sun H, Wurihan, Gegeheng, Gezi G, Skarstad K*, Fan L*, Morigen*. A DnaA-dependent riboswitch for transcription attenuation of the his operon, mLife, 2(2):126-140, 2023.

（2）Zhu W, Xi L, Qiao J, Du D, Wang Y, Morigen*. Involvement of OxyR and Dps in the repression of replication initiation by DsrA small RNA in Escherichia coli, Gene（三区，影响因子3.5）, 21:147659. doi: 10.1016/j.gene.2023.147659, 2023.

（3）Tian X, Nanding K, Dai X, Wang Q, Wang J, Morigen*, L Fan*. Pattern recognition receptor mediated innate immune response requires a Rif-dependent pathway，J Autoimmunity（一区TOP，影响因子12.8）, 134 (2023) 102975, 2022.

（4）Qiao J, Liang Y, Wang Y, Morigen*. Trimethylamine N-Oxide Reduces the Susceptibility of Escherichia coli to Multiple Antibiotics, Front Microbiol（二区TOP，影响因子5.2）, 13:956673.doi:10.3389/fmicb.2022.956673, 2022.

（5）Morigen*, Glinkowska M, J Xie. Editorial: bacterial transcription factors and the cell cycle, Front Microbiol （二区TOP，影响因子5.2）, 12:821394.doi: 10.3389/fmicb.2021.821394, 2021.

（6）Wu D, Baigalmaa L, Yao Y, Li G, Su M*, Fan L*, Morigen*. The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility, Gene（三区，影响因子3.5）, 773 (2021) 145374, 2021.

（7）Wurihan, Gezi, Brambilla E, Wang S, Sun H, Fan L, Shi Y1, Sclavi B*, Morigen*. DnaA and LexA proteins regulate transcription of the uvrB gene in Escherichia coli: the role of DnaA in the control of the SOS regulon, Front Microbiol（二区TOP，影响因子5.2）, 9:1212, https://doi.org/10.3389/fmicb.2018.01212, 2018.

（8）Yao Y, Enkhtsetseg S, Odsbu I, Fan L, Morigen*. Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1–1 plasmid, BMC Microbiol（三区，影响因子4.2）, 18:27, https://doi.org/10.1186/s12866-018-1162-3, 2018.

（9）Yao Y, Fan L, Shi Y, Odsbu I, Morigen*. A spatial control for correct timing of gene expression during the Escherichia coli cell cycle, Genes（三区，影响因子3.5）, 8(1), 1: doi:10.3390/genes8010001, 2017.

（10）Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen*. The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis, Oncotarget, doi:10.18632/oncotarget.16872, 2017.

（11）Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L*, Morigen*. AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle, PLoS ONE（三区，影响因子3.725）, 9(3):e92229, 2014.

（12）Morigen, Odsbu I, K Skarstad*. Growth rate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing Escherichia coli, Genes Cells, 14(5):643-657, 2009.

（13）Morigen, Molina F, K Skarstad*. Deletion of the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication, J Bacteriol（三区，影响因子3.467）, 187(12):3913-20, 2005.

（14）Morigen, Løbner-Olesen A, K Skarstad*. Titration of the Escherichia coli DnaA protein to excess datA sites causes destabilization of replication forks, delayed replication initiation and delayed cell division, Mol Microbiol（二区，影响因子3.6）, 50:349-362, 2003.

（15）Morigen, Glinkowska M, J Xie， E-book: eds，论著. Bacterial Transcription Factors and the Cell Cycle, Lausanne: Frontiers Media SA. doi: 10.3389/978-2-88974-324-7. ISBN 978-2-88974-324-7, 2022.

*示通讯作者